A Focus on Curcumin Local Application in Oral Diseases Management: Mini Review

Nutraceutical is a food or à food ingredient that provides medical and health benefits. Polyphenols play an important role in the maintenance of health and prevention of diseases. Among polyphenols, the most widely used substance Curcumin. Curcumin derived from the herbal remedy and dietary spice turmeric. It possesses wide range of beneficial properties includes anti-inflammatory, anti-oxidant, anti-microbial and anticancer properties following oral or topical administration, so it can be useful for both systemic and local disease treatments. Local drug delivery provides a more targeted and efficient drug-delivery option than systemic delivery. This review primarily focuses on some of the evidences on local therapeutic approaches of Curcumin for most common oral diseases; oral infection, periodontal diseases, aphthous ulcers, precancerous lesions and oral mucositis. This review also highlights the recent advances of nanocarriers’ delivery systems in enhancing and improving the local efficacy of Curcumin to combat specifically some of the oral diseases.